AEROSIL® 200 Pharma supports stable powder flow from feeding through to tabletting, even at low glidant dosing rates. It reduces flow-related disruptions, supports consistent die filling and helps minimise tablet weight variation, making it a central excipient for continuous direct compression processes.
AEROSIL® 200 Pharma by Evonik
AEROSIL® 200 Pharma is the industry-standard colloidal silica glidant used to improve powder flow, ensure homogeneous API distribution and support consistent tablet quality. Designed for pharmaceutical manufacturing environments, it plays a key role in both traditional batch processing and continuous direct compression.
Product description & functions
AEROSIL® 200 Pharma is a high-purity, colloidal silicon dioxide developed specifically for pharmaceutical applications. As a glidant, it reduces interparticulate forces within powder blends, improving flow behaviour, blend homogeneity and process reliability.
Its performance is particularly valuable in continuous direct compression, where consistent powder flow and precise dosing are essential. Even at low residence times and low feeding rates, AEROSIL® 200 Pharma distributes effectively across host particles, supporting stable processing and reproducible tablet properties.
Manufactured in line with IPEC-GMP guidelines and compliant with major pharmacopoeia monographs, AEROSIL® 200 Pharma offers both functional performance and regulatory confidence.
AEROSIL® 200 Pharma supports key manufacturing pathways
- Improves flowability of cohesive excipient and API blends
- Supports homogeneous API distribution at low concentrations
- Reduces powder retention in equipment and transfer lines
- Enhances consistency in tablet mass and mechanical strength
- Enables stable operation in continuous manufacturing concepts
Applications
Continuous direct compression
Batch tabletting and blending
In batch processes, AEROSIL® 200 Pharma improves blend uniformity and flowability, supporting reproducible tabletting and reduced batch-to-batch variability. Its effectiveness at low concentrations allows formulators to optimise performance without significantly altering formulation composition.
Challenging powder systems
For cohesive or poorly flowing powders, the glidant reduces van der Waals forces and helps eliminate liquid bridges between particles. This supports smoother handling, reduced sticking and more predictable compaction behaviour.
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Property
- Type
- Behaviour in water
- Specific surface area (BET)
- Tamped density
- Particle size (primary)
- Compliance
- Production
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Unit
- -
- -
- m²/g
- g/l
- nm
- -
- -
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Typical value
- Fumed colloidal silicon dioxide
- Hydrophilic
- approx. 200
- approx. 50
- approx. 12
- Ph. Eur., USP/NF “Colloidal Silicon Dioxide”
- GMP-compliant (IPEC guidelines)
